349 research outputs found
Laryngoscopic Image Stitching for View Enhancement and Documentation - First Experiences
One known problem within laryngoscopy is the spatially limited view onto the hypopharynx and the larynx through the endoscope. To examine the complete larynx and hypopharynx, the laryngoscope can be rotated about its main axis, and hence the physician obtains a complete view. If such examinations are captured using endoscopic video, the examination can be reviewed in detail at a later time. Nevertheless, in order to document the examination with a single representative image, a panorama image can be computed for archiving and enhanced documentation. Twenty patients with various clinical findings were examined with a 70 rigid laryngoscope, and the video sequences were digitally stored. The image sequence for each patient was then post-processed using an image stitching tool based on SIFT features, the RANSAC approach and blending. As a result, endoscopic panorama images of the larynx and pharynx were obtained for each video sequence. The proposed approach of image stitching for laryngoscopic video sequences offers a new tool for enhanced visual examination and documentation of morphologic characteristics of the larynx and the hypopharynx
A visão dos vencedores: O Brasil e a glorificação da Guerra do Paraguai nas exposições universais do século XIX
Between 1862 and 1889, the Empire of Brazil participated in the most important World’s Fairs in Europe and the United States. Especially within the scope of the exhibitions in Paris (1867), Vienna (1873), and Philadelphia (1876), one of the most frequently visualized topics was the Paraguayan War, which the exhibition organizers staged as an epical battle between “civilization” and “barbarism”. Besides, by constructing a “national memory” of the victory over the descendants of the indigenous GuaranĂ, generally considered as “savages”, Brazil sought to present itself as regional power as well as a society whose racial composition was about to change by the process of “whitening”.Entre 1862 e 1889, o impĂ©rio do Brasil participou das mais importantes exposições universais na Europa e nos Estados Unidos. Especialmente no contexto das exposições de Paris, em 1867, Viena, em 1873, e FiladĂ©lfia, em 1876, uma das temáticas mais frequentemente visualizadas foi a Guerra do Paraguai, posta em cena pelos organizadores das seções brasileiras como uma suposta luta entre “civilização” e “barbárie”. AlĂ©m disso, com a construção de uma “memĂłria nacional” da vitĂłria sobre os descendentes dos Ăndios guarani, considerados como “selvagens”, o Brasil pĂ´de-se mostrar no exterior como um paĂs em processo de “branqueamento” e uma potĂŞncia regional a ser levada a sĂ©rio
Huhle, Teresa. Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (Bielefeld: Transcript, 2017), 358 p.
(Spa) En Colombia, todavĂa son escasos los estudios que se dedican a investigar temas relacionados con planeaciĂłn familiar y demografĂa en una perspectiva transnacional. Como indica la historiadora Teresa Huhle en la introducciĂłn de su libro titulado Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (en castellano: “PoblaciĂłn, fertilidad y planeaciĂłn familiar en Colombia. Una historia transnacional del conocimiento en la Guerra FrĂa”), la mayorĂa de trabajos dedicados a esta temática usan el Estado-naciĂłn como marco analĂtico y, frecuentemente, son escritos por mĂ©dicos y funcionarios participantes de los programas de control de natalidad de los años 60. Lo anterior hace que muchos de estos estudios no solo sufran el sesgo del nacionalismo metodolĂłgico y oculten los numerosos vĂnculos demostrables que existĂan con expertos y entidades de otros paĂses, sino tambiĂ©n que prolifere un nĂşmero para nada despreciable de estudios institucionales y poco crĂticos
Huhle, Teresa. Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (Bielefeld: Transcript, 2017), 358 p.
En Colombia, todavĂa son escasos los estudios que se dedican a investigar temas relacionados con planeaciĂłn familiar y demografĂa en una perspectiva transnacional. Como indica la historiadora Teresa Huhle en la introducciĂłn de su libro titulado Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (en castellano: “PoblaciĂłn, fertilidad y planeaciĂłn familiar en Colombia. Una historia transnacional del conocimiento en la Guerra FrĂa”), la mayorĂa de trabajos dedicados a esta temática usan el Estado-naciĂłn como marco analĂtico y, frecuentemente, son escritos por mĂ©dicos y funcionarios participantes de los programas de control de natalidad de los años 60. Lo anterior hace que muchos de estos estudios no solo sufran el sesgo del nacionalismo metodolĂłgico y oculten los numerosos vĂnculos demostrables que existĂan con expertos y entidades de otros paĂses, sino tambiĂ©n que prolifere un nĂşmero para nada despreciable de estudios institucionales y poco crĂticos.En Colombia, todavĂa son escasos los estudios que se dedican a investigar temas relacionados con planeaciĂłn familiar y demografĂa en una perspectiva transnacional. Como indica la historiadora Teresa Huhle en la introducciĂłn de su libro titulado Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (en castellano: “PoblaciĂłn, fertilidad y planeaciĂłn familiar en Colombia. Una historia transnacional del conocimiento en la Guerra FrĂa”), la mayorĂa de trabajos dedicados a esta temática usan el Estado-naciĂłn como marco analĂtico y, frecuentemente, son escritos por mĂ©dicos y funcionarios participantes de los programas de control de natalidad de los años 60. Lo anterior hace que muchos de estos estudios no solo sufran el sesgo del nacionalismo metodolĂłgico y oculten los numerosos vĂnculos demostrables que existĂan con expertos y entidades de otros paĂses, sino tambiĂ©n que prolifere un nĂşmero para nada despreciable de estudios institucionales y poco crĂticos.En Colombia, todavĂa son escasos los estudios que se dedican a investigar temas relacionados con planeaciĂłn familiar y demografĂa en una perspectiva transnacional. Como indica la historiadora Teresa Huhle en la introducciĂłn de su libro titulado Bevölkerung, Fertilität und Familienplanung in Kolumbien. Eine transnationale Wissensgeschichte im Kalten Krieg (en castellano: “PoblaciĂłn, fertilidad y planeaciĂłn familiar en Colombia. Una historia transnacional del conocimiento en la Guerra FrĂa”), la mayorĂa de trabajos dedicados a esta temática usan el Estado-naciĂłn como marco analĂtico y, frecuentemente, son escritos por mĂ©dicos y funcionarios participantes de los programas de control de natalidad de los años 60. Lo anterior hace que muchos de estos estudios no solo sufran el sesgo del nacionalismo metodolĂłgico y oculten los numerosos vĂnculos demostrables que existĂan con expertos y entidades de otros paĂses, sino tambiĂ©n que prolifere un nĂşmero para nada despreciable de estudios institucionales y poco crĂticos
HMM Logos for visualization of protein families
BACKGROUND: Profile Hidden Markov Models (pHMMs) are a widely used tool for protein family research. Up to now, however, there exists no method to visualize all of their central aspects graphically in an intuitively understandable way. RESULTS: We present a visualization method that incorporates both emission and transition probabilities of the pHMM, thus extending sequence logos introduced by Schneider and Stephens. For each emitting state of the pHMM, we display a stack of letters. The stack height is determined by the deviation of the position's letter emission frequencies from the background frequencies. The stack width visualizes both the probability of reaching the state (the hitting probability) and the expected number of letters the state emits during a pass through the model (the state's expected contribution). A web interface offering online creation of HMM Logos and the corresponding source code can be found at the Logos web server of the Max Planck Institute for Molecular Genetics . CONCLUSIONS: We demonstrate that HMM Logos can be a useful tool for the biologist: We use them to highlight differences between two homologous subfamilies of GTPases, Rab and Ras, and we show that they are able to indicate structural elements of Ras
Untersuchung der Bedeutung des P-Glykoproteins fĂĽr die Penetration von AT1-Rezeptorantagonisten durch die Blut-Hirn-Schranke
Diese Arbeit beschäftigte sich mit der Penetrationsfähigkeit der Blut-Hirn-Schranke hinsichtlich vier AT-1-Rezeptorantagonisten vor dem Hintergrund einer möglichen protektiven Wirkung im Postinfarktgeschehen. Hierzu wurde eine aufwendige Tierversuchsreihe genutzt. Es zeigte sich, dass die Hemmung des P-Glykoproteins mittels Verapamil zu einer erhöhten Konzentration von Candesartan im ZNS führte. Es muss jedoch auf die Möglichkeit einer Interaktion mit anderen Transportern hingewiesen werden
MALDI mass spectrometry imaging workflow for the aquatic model organisms Danio rerio and Daphnia magna
Lipids play various essential roles in the physiology of animals. They are also highly dependent on cellular metabolism or status. It is therefore crucial to understand to which extent animals can stabilize their lipid composition in the presence of external stressors, such as chemicals that are released into the environment. We developed a MALDI MS imaging workflow for two important aquatic model organisms, the zebrafish (Danio rerio) and water flea (Daphnia magna). Owing to the heterogeneous structure of these organisms, developing a suitable sample preparation workflow is a highly non-trivial but crucial part of this work and needs to be established first. Relevant parameters and practical considerations in order to preserve tissue structure and composition in tissue sections are discussed for each application. All measurements were based on high mass accuracy enabling reliable identification of imaged compounds. In zebrafish we demonstrate that a detailed mapping between histology and simultaneously determined lipid composition is possible at various scales, from extended structures such as the brain or gills down to subcellular structures such as a single axon in the central nervous system. For D. magna we present for the first time a MALDI MSI workflow, that demonstrably maintains tissue integrity during cryosectioning of non-preserved samples, and allows the mapping of lipids in the entire body and the brood chamber inside the carapace. In conclusion, the lipid signatures that we were able to detect with our method provide an ideal basis to analyze changes caused by pollutants in two key aquatic model organisms
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